Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 12/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5413635 | 0.84 | CDC25B (0.45) | LMNAMAPTHTTNPSR1POLB | |
| SCHEMBL5431261 | 0.77 | MAPT (0.38) | LMNAMAPTHTTNPSR1POLB | |
| SCHEMBL5402882 | 0.71 | CDC25B (0.60) | LMNAMAPTHTTNPSR1SMN1; SMN2 | |
| SCHEMBL5745140 | 0.71 | GFPT1 (0.48) | LMNAMAPTHTTEGFRERBB2 | |
| SCHEMBL5744098 | 0.71 | EGFR (0.52) | MAPTNPSR1SMN1; SMN2EGFRERBB2 | |
| SCHEMBL5744897 | 0.70 | GFPT1 (0.51) | EGFRERBB2MAP2K1SRC | |
| SCHEMBL5744902 | 0.69 | GFPT1 (0.47) | EGFRERBB2MAP2K1 | |
| SCHEMBL7467937 | 0.68 | MAPT (0.42) | LMNAMAPTHTTNPSR1POLB | |
| SCHEMBL30104266 | 0.66 | MAP2K1 (0.51) | EGFRERBB2MAP2K1SRC | |
| SCHEMBL5394717 | 0.66 | CDC25B (0.49) | EGFRERBB2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675845-A2 | GLUTAMINE FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE (GFAT) INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-05 | — | — | EP | disclosed |
| US-7037924-B2 | Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2006-05-02 | — | — | US | disclosed |
| US-20050113407-A1 | Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors | BOLIN DAVID R (US) | 2005-05-26 | — | — | US | disclosed |
| WO-2005040150-A2 | GLUTAMINE FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE (GFAT) INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113407-A1 | Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors | GFPT1, GLS2, GLUL | LMNA 4835/4885MAPT 2258/4885HTT 2398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.