Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 7/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | FPR1 | P21462 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359237 | 0.86 | KIF11 (0.53) | GAAALDH1A1SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL6454042 | 0.78 | KIF11 (0.62) | GAAALDH1A1CYP3A4CYP2C19KIF11 | |
| SCHEMBL1386243 | 0.76 | LMNA (0.50) | GAAALDH1A1SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL5752668 | 0.74 | KIF11 (0.70) | CYP3A4CYP2C19KIF11 | |
| SCHEMBL5758518 | 0.72 | KIF11 (0.53) | CYP3A4CYP2C19KIF11 | |
| SCHEMBL5755244 | 0.72 | KIF11 (0.49) | CYP3A4CYP2C19KIF11 | |
| SCHEMBL5756110 | 0.71 | KIF11 (0.57) | CYP3A4CYP2C19KIF11 | |
| SCHEMBL5754790 | 0.70 | KIF11 (0.52) | CYP3A4CYP2C19KIF11 | |
| SCHEMBL5863323 | 0.67 | KIF11 (0.62) | GAAKIF11TP53PPARGFPR1 | |
| SCHEMBL5754619 | 0.67 | KIF11 (0.53) | SMN1; SMN2CYP3A4CYP2C19KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503993-A4 | COMPOUNDS, METHODS AND COMPOSITIONS | CYTOKINETICS INC (US) | 2006-05-03 | — | — | EP | disclosed |
| EP-1503993-A2 | COMPOUNDS, METHODS AND COMPOSITIONS | Cytokinetics, Inc. (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003094839-A2 | PYRIMIDINONE COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2003-11-20 | — | — | WO | disclosed |