Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16960215 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2GLACSNK2A1NPC1RAB9A | |
| SCHEMBL26641603 | 0.84 | TNKS2 (0.51) | SMN1; SMN2GLATNKS2CYP4A11 | |
| SCHEMBL8308188 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2GLACSNK2A1NPC1RAB9A | |
| SCHEMBL3332061 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2GLACSNK2A1NPC1RAB9A | |
| SCHEMBL15022597 | 0.78 | MEN1 (0.48) | SMN1; SMN2TNKS2CYP4A11PPARG | |
| SCHEMBL5760155 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2GLACSNK2A1NPC1RAB9A | |
| SCHEMBL7467338 | 0.76 | ALDH1A1 (0.50) | SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL5758935 | 0.75 | CYP4F2 (0.50) | SMN1; SMN2GLAHPGDCYP4A11ATM | |
| SCHEMBL31265277 | 0.74 | TNKS2 (0.56) | GLATNKS2CYP4A11ATMMAPT | |
| SCHEMBL16954839 | 0.74 | SMN1; SMN2 (0.52) | SMN1; SMN2GLACSNK2A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1270571-B1 | Heterocyclic compounds, their production and use | TAKEDA PHARMACEUTICAL (JP) | 2006-09-06 | — | — | EP | disclosed |
| EP-1270571-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-01-02 | — | — | EP | disclosed |
| CN-1349990-A | Heterocyclic compound, its preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-05-22 | — | — | CN | disclosed |
| CN-1077107-C | Heterocyclic compounds, their preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-02 | — | — | CN | disclosed |
| US-6211215-B1 | AROMATIC HETEROCYCLIC COMPOUND WITH AZOLE COMPOUND | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| CN-1223653-A | Heterocyclic compounds, their preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-07-21 | — | — | CN | disclosed |