SCHEMBL5760029

SCHEMBL5760029

N#Cc1ccc(-c2nc(CCl)co2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 2/20 0.47
PTPN11 Q06124 1/20 0.41
DRD2 P14416 1/20 0.38
DRD4 P21917 1/20 0.38
DRD3 P35462 1/20 0.38
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
GSK3B P49841 2/20 0.38
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA9 Q16790 1/20 0.37
CYP19A1 P11511 1/20 0.37
S1PR1 P21453 1/20 0.36
S1PR3 Q99500 1/20 0.36
MMP13 P45452 2/20 0.36
NPC1 O15118 1/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10313028 0.85 NOTUM (0.49) NOTUMDRD2DRD4DRD3MAOA
SCHEMBL1157995 0.84 NOTUM (0.47) NOTUMDRD2DRD4DRD3MAOA
SCHEMBL1158490 0.84 NOTUM (0.47) NOTUMDRD2DRD4DRD3MAOA
SCHEMBL2225654 0.81 NOTUM (0.45) NOTUMDRD2DRD4DRD3MAOA
SCHEMBL13807290 0.80 PTPN11 (0.45) PTPN11DRD2DRD4DRD3NPC1
SCHEMBL202513 0.80 NPC1 (0.51) NOTUMPTPN11DRD2DRD4DRD3
SCHEMBL3070107 0.78 PTPN11 (0.50) PTPN11DRD2DRD4DRD3NPC1
SCHEMBL2107124 0.78 LMNA (0.52) NOTUMPTPN11DRD2DRD4DRD3
SCHEMBL203359 0.78 HDAC1 (0.46) NOTUMPTPN11DRD2DRD4DRD3
SCHEMBL2225496 0.78 HDAC1 (0.47) PTPN11DRD2DRD4DRD3NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1270571-B1 Heterocyclic compounds, their production and use TAKEDA PHARMACEUTICAL (JP) 2006-09-06 EP disclosed
EP-1270571-A1 Heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-01-02 EP disclosed
CN-1349990-A Heterocyclic compound, its preparation and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2002-05-22 CN disclosed
CN-1077107-C Heterocyclic compounds, their preparation and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2002-01-02 CN disclosed
US-6211215-B1 AROMATIC HETEROCYCLIC COMPOUND WITH AZOLE COMPOUND TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-04-03 US disclosed
CN-1223653-A Heterocyclic compounds, their preparation and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-07-21 CN disclosed
EP-0912562-A1 HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1999-05-06 EP disclosed
WO-1998003505-A2 HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-01-29 WO disclosed