Sugi Predict

Sugi Predict / Compounds / SCHEMBL203359

SCHEMBL203359

SCHEMBL203359

Cc1ccc(-c2nc(CCl)co2)cc1

nearest known ligand 0.54

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ HDAC1 Q13547 1/20 0.46
▸ HDAC8 Q9BY41 1/20 0.46
▸ HDAC6 Q9UBN7 1/20 0.46
▸ PTPN11 Q06124 1/20 0.44
▸ NOTUM Q6P988 1/20 0.42
▸ DRD2 P14416 1/20 0.41
▸ DRD4 P21917 1/20 0.41
▸ DRD3 P35462 1/20 0.41
▸ ENPP3 O14638 1/20 0.41
▸ ENPP1 P22413 1/20 0.41
▸ NR1H4 Q96RI1 1/20 0.40
▸ PDE4B Q07343 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28938192 0.92 HDAC1 (0.41) HDAC1HDAC8HDAC6PTPN11NOTUM
SCHEMBL202513 0.84 NPC1 (0.51) HDAC1HDAC8HDAC6PTPN11NOTUM
SCHEMBL13807290 0.84 PTPN11 (0.45) PTPN11DRD2DRD4DRD3
SCHEMBL13503419 0.84 HDAC1 (0.47) HDAC1HDAC8HDAC6NOTUMENPP3
SCHEMBL3070107 0.82 PTPN11 (0.50) PTPN11DRD2DRD4DRD3PDE4B
SCHEMBL2107124 0.82 LMNA (0.52) HDAC1HDAC8HDAC6PTPN11NOTUM
SCHEMBL6977195 0.82 PTPN11 (0.44) PTPN11DRD2DRD4DRD3
SCHEMBL2225496 0.82 HDAC1 (0.47) HDAC1HDAC8HDAC6PTPN11DRD2
SCHEMBL1051422 0.82 HDAC1 (0.46) HDAC1HDAC8HDAC6NOTUMENPP3
SCHEMBL5761885 0.82 PTPN11 (0.47) PTPN11NOTUMDRD2DRD4DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250179008-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. (US) 2025-06-05 — — US disclosed
US-12016852-B2 Pyrrolidine glycosidase inhibitors ASCENEURON SA (CH) 2024-06-25 — — US disclosed
CN-114516868-B N-heteroaryl methyl difluoromethyl pyrimidine amine compound, and preparation method and application thereof 湖南海利常德农药化工有限公司 2024-02-27 — — CN disclosed
US-20230357221-A1 HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF UNIV MONTREAL (CA) 2023-11-09 — — US disclosed
US-11760754-B2 Heterocyclic mitochondrial activity inhibitors and uses thereof Université de Montréal (CA) 2023-09-19 — — US disclosed
CN-114516868-A N-heteroaryl methyl difluoromethyl pyrimidinamine compound and preparation method and application thereof 湖南海利常德农药化工有限公司 2022-05-20 — — CN disclosed
US-20210213005-A1 PYRROLIDINE GLYCOSIDASE INHIBITORS ASCENEURON SA (CH) 2021-07-15 — — US disclosed
CN-111978268-A 1- (4-chlorphenyl) -2-cyclopropyl acetone oxime oxazole methyl ether and application thereof 湖南大学 2020-11-24 — — CN disclosed
WO-2020039027-A1 PYRROLIDINE GLYCOSIDASE INHIBITORS ASCENEURON S. A. (CH) 2020-02-27 — — WO disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 — — US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 — — US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 — — US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 — — US disclosed
CN-101404989-A Antibacterial agent PROLYSIS LTD (GB) 2009-04-08 — — CN disclosed
EP-1996180-A1 ANTIBACTERIAL AGENTS Prolysis Limited (GB) 2008-12-03 — — EP disclosed
US-20080167307-A1 Carboxylic Acid Derivative Containing Thiazole Ring and Pharmaceutical Use Thereof MITSUBISHI PHAMA CORPORATION (JP) 2008-07-10 — — US disclosed
US-20080167307-A1 Carboxylic Acid Derivative Containing Thiazole Ring and Pharmaceutical Use Thereof MITSUBISHI PHAMA CORPORATION (JP) 2008-07-10 — — US disclosed
WO-2007107758-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2007-09-27 — — WO disclosed
WO-2007107758-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2007-09-27 — — WO disclosed
EP-1816128-A1 CARBOXYLIC ACID DERIVATIVE CONTAINING THIAZOLE RING AND PHARMACEUTICAL USE THEREOF Mitsubishi Pharma Corporation (JP) 2007-08-08 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080167307-A1 Carboxylic Acid Derivative Containing Thiazole Ring and Pharmaceutical Use Thereof PPARA, PPARD, PPARG HDAC1 454/4885HDAC8 581/4885HDAC6 413/4885
US-20230357221-A1 HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF IDH2, TFAM, IDH1 HDAC1 190/4885HDAC8 93/4885HDAC6 638/4885
US-12016852-B2 Pyrrolidine glycosidase inhibitors PREP, GAA, DNPEP HDAC1 422/4885HDAC8 923/4885HDAC6 317/4885
US-20150191420-A1 ANTIBACTERIAL AGENTS ALK, ARG1, ROS1 HDAC1 854/4885HDAC8 3350/4885HDAC6 2565/4885
US-20210213005-A1 PYRROLIDINE GLYCOSIDASE INHIBITORS PREP, GAA, DNPEP HDAC1 384/4885HDAC8 836/4885HDAC6 274/4885
US-20250179008-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 HDAC1 801/4885HDAC8 2722/4885HDAC6 2483/4885
US-20100173933-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 HDAC1 801/4885HDAC8 2722/4885HDAC6 2483/4885
US-11760754-B2 Heterocyclic mitochondrial activity inhibitors and uses thereof IDH2, TFAM, NUTF2 HDAC1 255/4885HDAC8 153/4885HDAC6 624/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.