Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5760072 | 1.00 | LMNA (0.49) | LMNASMN1; SMN2KDM4ENFKB1NFKB2 | |
| SCHEMBL5755065 | 0.89 | TAS1R3 (0.44) | LMNASMN1; SMN2KDM4ENFKB1NFKB2 | |
| SCHEMBL5755063 | 0.89 | TAS1R3 (0.44) | LMNASMN1; SMN2KDM4ENFKB1NFKB2 | |
| SCHEMBL5759135 | 0.81 | KDM4E (0.69) | LMNASMN1; SMN2KDM4ENFKB1NFKB2 | |
| SCHEMBL5757247 | 0.80 | NPC1 (0.65) | LMNASMN1; SMN2KDM4ENFKB1NFKB2 | |
| SCHEMBL5755017 | 0.73 | NPC1 (0.47) | SMN1; SMN2KDM4EHDAC6MAPTRAB9A | |
| SCHEMBL5759668 | 0.73 | KDM4E (0.51) | LMNASMN1; SMN2KDM4ENFKB1NFKB2 | |
| SCHEMBL2789030 | 0.72 | PIK3CA (0.55) | LMNASMN1; SMN2KDM4ENFKB1NFKB2 | |
| SCHEMBL5752924 | 0.71 | APP (0.54) | LMNASMN1; SMN2KDM4ENFKB1NFKB2 | |
| SCHEMBL5756224 | 0.70 | HPGD (0.55) | LMNASMN1; SMN2KDM4ENFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539723-B1 | NOVEL USE OF BENZOTHIAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-05-24 | — | — | EP | claimed |