Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1544714 | 0.91 | LMNA (0.55) | POLBLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1544672 | 0.79 | ALDH1A1 (0.59) | POLBLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1543533 | 0.78 | ALDH1A1 (0.54) | POLBLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1544695 | 0.77 | MEN1 (0.59) | POLBLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1543910 | 0.76 | ALDH1A1 (0.55) | POLBLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1544432 | 0.75 | MEN1 (0.56) | POLBLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1543817 | 0.68 | MEN1 (0.58) | POLBLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1544531 | 0.68 | ALDH1A1 (0.55) | POLBALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL1544053 | 0.68 | ALDH1A1 (0.59) | POLBLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1544593 | 0.67 | LMNA (0.58) | POLBLMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723144-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2006-11-22 | — | — | EP | disclosed |
| WO-2006014185-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-02-09 | — | — | WO | disclosed |