Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2478239 | 0.84 | SLC6A4 (0.33) | — | |
| SCHEMBL188649 | 0.83 | HRH3 (0.40) | HRH3CHRM3SMN1; SMN2 | |
| SCHEMBL189066 | 0.78 | MRGPRX2 (0.36) | HRH3CHRM3 | |
| SCHEMBL693535 | 0.77 | IKBKB (0.39) | — | |
| SCHEMBL2481875 | 0.69 | SLC6A4 (0.32) | — | |
| SCHEMBL15323562 | 0.68 | LTA4H (0.36) | GAA | |
| SCHEMBL17308547 | 0.67 | HRH3 (0.68) | HRH3SMN1; SMN2GAA | |
| SCHEMBL2476107 | 0.66 | CHRNA7 (0.42) | HRH3SMN1; SMN2GAA | |
| SCHEMBL8391744 | 0.66 | HRH3 (0.67) | HRH3CARM1PRMT6SMN1; SMN2GAA | |
| SCHEMBL4587168 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622611-A1 | IMIDAZOLIN-2-YLAMINOPHENYL AMIDES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096213-A1 | IMIDAZOLIN-2-YLAMINOPHENYL AMIDES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-11 | — | — | WO | disclosed |