Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.63 |
| ▸ | BRAF | P15056 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463764 | 0.82 | MAPK14 (0.91) | MAPK14MAPK13MAPK12MAPK11PTGS1 | |
| SCHEMBL4105858 | 0.81 | MAPK13 (0.60) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL4096709 | 0.80 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL5759775 | 0.78 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11PRKD3 | |
| SCHEMBL4101328 | 0.77 | TGFBR1 (0.41) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL5762949 | 0.77 | MAPK13 (0.62) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL4091788 | 0.76 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11PTGS1 | |
| SCHEMBL4114563 | 0.76 | BRAF (1.00) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL4585275 | 0.76 | BRAF (1.00) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL5763554 | 0.75 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414443-B1 | BENZIMIDAZO 4,5-f|ISOQUINOLINONE DERIVATIVES | MERCK & CO INC (US) | 2006-11-15 | — | — | EP | disclosed |
| EP-1414443-A4 | BENZIMIDAZO 4,5-f]ISOQUINOLINONE DERIVATIVES | MERCK & CO INC (US) | 2005-05-11 | — | — | EP | disclosed |
| US-6852727-B2 | Benzimisazo[4,5-f]isoquinolinone derivatives | MERCK & CO., INC. (US) | 2005-02-08 | — | — | US | disclosed |
| US-20040176601-A1 | Benzimisazo[4,5-f]isoquinolinone derivatives | MERCK SHARP & DOHME LLC | 2004-09-09 | — | — | US | disclosed |
| EP-1414443-A1 | BENZIMIDAZO 4,5-f]ISOQUINOLINONE DERIVATIVES | Merck & Co., Inc. (US) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003011285-A1 | BENZIMIDAZO[4,5-f]ISOQUINOLINONE DERIVATIVES | MERCK & CO., INC. (US) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176601-A1 | Benzimisazo[4,5-f]isoquinolinone derivatives | JAK1, JAK3, JAK2 | MAPK14 73/4885MAPK13 271/4885MAPK12 288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.