Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 1.00 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 13/20 | 0.66 |
| ▸ | MAPK12 | P53778 | 13/20 | 0.66 |
| ▸ | MAPK11 | Q15759 | 13/20 | 0.66 |
| ▸ | GCGR | P47871 | 12/20 | 0.64 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.64 |
| ▸ | FRK | P42685 | 3/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.64 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.64 |
| ▸ | GSK3B | P49841 | 3/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.64 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.64 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.58 |
| ▸ | PRKACA | P17612 | 2/20 | 0.57 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.57 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585275 | 1.00 | BRAF (1.00) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL7163768 | 0.82 | BRAF (0.69) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4108151 | 0.82 | BRAF (0.69) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL14529599 | 0.82 | BRAF (0.69) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL19857269 | 0.81 | GCGR (0.79) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27335373 | 0.80 | MAPK14 (0.69) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1692321 | 0.80 | BRAF (0.66) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1692122 | 0.80 | BRAF (0.66) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4460547 | 0.79 | MAPK14 (1.00) | BRAFMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13712659 | 0.79 | MAPK14 (1.00) | BRAFMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227602-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2009-09-10 | — | — | US | disclosed |
| US-20090227602-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2009-09-10 | — | — | US | disclosed |
| US-20090227602-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2009-09-10 | — | — | US | disclosed |
| EP-1948168-A2 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | Numerate, Inc (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007051065-A2 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. (US) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227602-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | HMGCR, HMGB3, HMGB2 | BRAF 1347/4885MAPK14 203/4885MAPK13 194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.