Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL339928 | 0.77 | BACE1 (0.63) | BACE1KMT2AHSP90AA1RAB9AMEN1 | |
| SCHEMBL30657716 | 0.77 | BACE1 (0.63) | BACE1KMT2AHSP90AA1RAB9AMEN1 | |
| SCHEMBL672744 | 0.77 | METAP2 (0.63) | KMT2AHSP90AA1RAB9AMEN1NPC1 | |
| SCHEMBL30082244 | 0.77 | METAP2 (0.63) | KMT2AHSP90AA1RAB9AMEN1NPC1 | |
| SCHEMBL7983249 | 0.77 | BACE1 (0.56) | BACE1RAB9ANPC1ARNQO2 | |
| SCHEMBL8467827 | 0.76 | METAP2 (0.61) | KMT2AHSP90AA1RAB9AMEN1NPC1 | |
| SCHEMBL413180 | 0.76 | METAP2 (0.61) | KMT2AHSP90AA1RAB9AMEN1NPC1 | |
| SCHEMBL16444064 | 0.76 | METAP2 (0.61) | KMT2AHSP90AA1RAB9AMEN1NPC1 | |
| Ammonia Solution, Strong SCHEMBL3284067 | 0.76 | METAP2 (0.61) | KMT2AHSP90AA1RAB9AMEN1NPC1 | |
| SCHEMBL6540982 | 0.76 | METAP2 (0.61) | KMT2AHSP90AA1RAB9AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119241559-A | Quinazoline macrocyclic compound serving as HPK1 kinase inhibitor and preparation method and application thereof | 深圳市新樾生物科技有限公司 | 2025-01-03 | — | — | CN | disclosed |
| CN-101289442-A | Novel benzoimidazole derivatives useful as antiproliferative agents | PFIZER PROD INC (US) | 2008-10-22 | — | — | CN | disclosed |
| US-7019147-B1 | Benzimidazole derivatives useful as antiproliferative agents | PFIZER INC. (US) | 2006-03-28 | — | — | US | disclosed |
| EP-1235825-B1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PROD INC (US) | 2006-01-25 | — | — | EP | disclosed |
| CN-1402721-A | Novel benzimidazole derivatives as antiproliferative agents | PFIZER PROD INC (US) | 2003-03-12 | — | — | CN | disclosed |
| EP-1235825-A1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | Pfizer Products Inc. (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001040217-A1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PRODUCTS INC. (US) | 2001-06-07 | — | — | WO | disclosed |