Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET known ✓ | P07949 | 1/20 | 0.61 |
| ▸ | PDGFRB known ✓ | P09619 | 1/20 | 0.61 |
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 0.61 |
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.61 |
| ▸ | GAK | O14976 | 1/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | ULK1 | O75385 | 1/20 | 0.61 |
| ▸ | STK10 | O94804 | 1/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.61 |
| ▸ | LATS1 | O95835 | 1/20 | 0.61 |
| ▸ | PAK4 | O96013 | 1/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | CDK1 | P06493 | 1/20 | 0.61 |
| ▸ | APRT | P07741 | 1/20 | 0.61 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.61 |
| ▸ | NQO2 | P16083 | 1/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29678517 | 0.90 | IRAK4 (0.72) | IRAK4GAKRIPK2ULK1STK10 | |
| SCHEMBL31060494 | 0.90 | IRAK4 (0.72) | IRAK4GAKRIPK2ULK1STK10 | |
| SCHEMBL859537 | 0.90 | IRAK4 (0.72) | IRAK4GAKRIPK2ULK1STK10 | |
| SCHEMBL5764487 | 0.86 | IRAK4 (0.51) | IRAK4GAKRIPK2ULK1STK10 | |
| SCHEMBL5766267 | 0.86 | IRAK4 (0.66) | IRAK4GAKRIPK2ULK1STK10 | |
| SCHEMBL5766257 | 0.86 | IRAK4 (0.66) | IRAK4GAKRIPK2ULK1STK10 | |
| SCHEMBL5764297 | 0.86 | IRAK4 (0.66) | IRAK4GAKRIPK2ULK1STK10 | |
| SCHEMBL5764385 | 0.84 | IRAK4 (0.61) | IRAK4GAKRIPK2ULK1STK10 | |
| SCHEMBL5763184 | 0.83 | IRAK4 (0.71) | IRAK4GAKRIPK2ULK1STK10 | |
| SCHEMBL5764257 | 0.82 | IRAK4 (0.61) | IRAK4GAKRIPK2ULK1STK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7019147-B1 | Benzimidazole derivatives useful as antiproliferative agents | PFIZER INC. (US) | 2006-03-28 | — | — | US | disclosed |
| EP-1235825-B1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PROD INC (US) | 2006-01-25 | — | — | EP | disclosed |