Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764608 | 0.93 | KMT2A (0.54) | KDM4EKMT2AHSD17B10MAPK14LRRK2 | |
| SCHEMBL5766791 | 0.83 | MAPK14 (0.47) | KDM4EHSD17B10MAPK14LRRK2 | |
| SCHEMBL5765439 | 0.82 | MAPK14 (0.40) | KDM4EKMT2AHSD17B10MAPK14LRRK2 | |
| SCHEMBL5767477 | 0.81 | HSD11B1 (0.43) | KDM4EKMT2AHSD17B10MAPK14LRRK2 | |
| SCHEMBL5767610 | 0.76 | MAPK14 (0.70) | MAPK14 | |
| SCHEMBL5764833 | 0.75 | MAPK14 (0.50) | KDM4EMAPK14LRRK2ALDH1A1HSD11B1 | |
| SCHEMBL5764736 | 0.74 | HSD11B1 (0.44) | MAPK14LRRK2ALDH1A1HPGDHSD11B1 | |
| SCHEMBL5765435 | 0.73 | MAPK14 (0.48) | KDM4EMAPK14LRRK2ALDH1A1HSD11B1 | |
| SCHEMBL5763436 | 0.73 | MAPK14 (0.48) | MAPK14LRRK2HSD11B1 | |
| SCHEMBL5766110 | 0.73 | MAPK14 (0.47) | KDM4EKMT2AHSD17B10MAPK14TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1601672-B1 | TRIAZOLO-PYRIDINES AS ANTI-INFLAMMATORY COMPOUNDS | PFIZER PROD INC (US) | 2006-07-26 | — | — | EP | disclosed |