Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764736 | 0.93 | HSD11B1 (0.44) | HSD11B1ALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL5764608 | 0.83 | KMT2A (0.54) | HSD11B1ALDH1A1SMN1; SMN2LMNAMAPK14 | |
| SCHEMBL5763351 | 0.82 | MAPK14 (0.56) | MAPK14 | |
| SCHEMBL5765041 | 0.81 | KDM4E (0.54) | HSD11B1ALDH1A1MAPK14LRRK2KDM4E | |
| SCHEMBL5766027 | 0.78 | MAPK14 (0.73) | MAPK14 | |
| Hydrochloric Acid SCHEMBL4082863 | 0.78 | MAPK14 (0.44) | HSD11B1ALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL5765439 | 0.77 | MAPK14 (0.40) | MAPK14LRRK2KDM4EKMT2AHSD17B10 | |
| SCHEMBL4072097 | 0.76 | HSD11B1 (0.49) | HSD11B1ALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL15007237 | 0.76 | HSD11B1 (0.52) | HSD11B1ALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL5766791 | 0.74 | MAPK14 (0.47) | MAPK14LRRK2KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1601672-B1 | TRIAZOLO-PYRIDINES AS ANTI-INFLAMMATORY COMPOUNDS | PFIZER PROD INC (US) | 2006-07-26 | — | — | EP | disclosed |