Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.33 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
| ▸ | CCND1 | P24385 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5767116 | 0.93 | KDM4E (0.34) | KDM4EMAPTCCNE2CCNE1CDK2 | |
| SCHEMBL5766555 | 0.93 | HDAC1 (0.36) | KDM4EMAPTHDAC3HDAC1HDAC2 | |
| SCHEMBL5679654 | 0.93 | HDAC3 (0.35) | KDM4EMAPTHDAC3HDAC1HDAC2 | |
| SCHEMBL14371336 | 0.92 | KDM4E (0.34) | KDM4EMAPTCCNE2CCNE1CDK2 | |
| SCHEMBL3957687 | 0.92 | KDM4E (0.34) | KDM4EMAPTCCNE2CCNE1CDK2 | |
| SCHEMBL5766426 | 0.89 | KDM4E (0.36) | KDM4EMAPTCCNE2CCNE1CDK2 | |
| SCHEMBL3951080 | 0.89 | PDK1 (0.45) | — | |
| SCHEMBL4688651 | 0.89 | PDK1 (0.45) | — | |
| SCHEMBL5763655 | 0.89 | PDK1 (0.45) | — | |
| SCHEMBL5765951 | 0.89 | KDM4E (0.32) | KDM4EMAPTCCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979821-B1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2006-09-13 | — | — | EP | disclosed |
| US-6211227-B1 | SULFUR CONTAINING TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0979821-A1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-02-16 | — | — | EP | disclosed |