Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5765490 | 0.93 | KDM4E (0.37) | HDAC3HDAC1HDAC2KDM4EMAPT | |
| SCHEMBL5766555 | 0.92 | HDAC1 (0.36) | HDAC3HDAC1HDAC2KDM4EMAPT | |
| SCHEMBL5767116 | 0.92 | KDM4E (0.34) | KDM4EMAPTCCNE2CCNE1CDK2 | |
| SCHEMBL14371336 | 0.91 | KDM4E (0.34) | KDM4EMAPTCCNE2CCNE1CDK2 | |
| SCHEMBL3957687 | 0.91 | KDM4E (0.34) | KDM4EMAPTCCNE2CCNE1CDK2 | |
| SCHEMBL3951080 | 0.90 | PDK1 (0.45) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL4688651 | 0.90 | PDK1 (0.45) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL5765951 | 0.90 | KDM4E (0.32) | KDM4EMAPTCCNE2CCNE1CDK2 | |
| SCHEMBL5763655 | 0.90 | PDK1 (0.45) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL3624678 | 0.89 | KDM4E (0.33) | KDM4EMAPTCCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979821-B1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2006-09-13 | — | — | EP | disclosed |
| EP-1611888-A1 | ANTITUSSIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-01-04 | — | — | EP | disclosed |
| US-20040248926-A1 | Preventive or remedy for pruritus | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2004-12-09 | — | — | US | disclosed |
| EP-1444980-A1 | PREVENTIVE OR REMEDY FOR PRURITUS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2004-08-11 | — | — | EP | disclosed |
| US-6211227-B1 | SULFUR CONTAINING TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0979821-A1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-02-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248926-A1 | Preventive or remedy for pruritus | ITCH, HRH2, HRH1 | HDAC3 1629/4885HDAC1 2006/4885HDAC2 1222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.