Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 3/20 | 0.46 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.46 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.46 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 14/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 14/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 14/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 14/20 | 0.42 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766659 | 0.93 | ABCC9 (0.48) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5766420 | 0.89 | ABCC9 (0.43) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5764157 | 0.89 | PDK1 (0.47) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5766501 | 0.88 | PDK1 (0.48) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5765963 | 0.88 | PDK1 (0.44) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5766421 | 0.86 | PDK1 (0.48) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5765706 | 0.86 | PDK1 (0.47) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5767321 | 0.82 | PDK1 (0.44) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5767047 | 0.81 | PDK1 (0.43) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5766112 | 0.80 | PDK1 (0.42) | ABCC9ABCC8KCNJ11KCNJ8PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979821-B1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2006-09-13 | — | — | EP | disclosed |
| US-6211227-B1 | SULFUR CONTAINING TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0979821-A1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-02-16 | — | — | EP | disclosed |