Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5765435 | 0.88 | MAPK14 (0.48) | MAPK14TNK2LRRK2GRM2 | |
| SCHEMBL5763436 | 0.85 | MAPK14 (0.48) | MAPK14LRRK2GRM2 | |
| SCHEMBL5764833 | 0.82 | MAPK14 (0.50) | MAPK14LRRK2GRM2 | |
| SCHEMBL5764665 | 0.80 | MAPK14 (0.48) | MAPK14RAB9ANPSR1 | |
| SCHEMBL5766791 | 0.72 | MAPK14 (0.47) | MAPK14LRRK2 | |
| SCHEMBL5765684 | 0.70 | MAPK14 (0.49) | MAPK14RAB9ANPC1 | |
| SCHEMBL4823102 | 0.70 | MAPK14 (0.59) | MAPK14 | |
| SCHEMBL15007180 | 0.69 | MAPK14 (0.60) | MAPK14GRM2 | |
| SCHEMBL5772879 | 0.69 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL25528705 | 0.68 | GRM2 (0.55) | MAPK14GRM2RAB9ANPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1601672-B1 | TRIAZOLO-PYRIDINES AS ANTI-INFLAMMATORY COMPOUNDS | PFIZER PROD INC (US) | 2006-07-26 | — | — | EP | disclosed |