Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 16/20 | 0.61 |
| ▸ | ICOSLG | O75144 | 9/20 | 0.61 |
| ▸ | ICOS | Q9Y6W8 | 9/20 | 0.61 |
| ▸ | IKBKB | O14920 | 3/20 | 0.61 |
| ▸ | TYK2 | P29597 | 1/20 | 0.61 |
| ▸ | CLK1 | P49759 | 1/20 | 0.61 |
| ▸ | CLK2 | P49760 | 1/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.61 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1802564 | 0.88 | CHUK (0.77) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL17225471 | 0.79 | CHUK (0.81) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL1798941 | 0.78 | CHUK (0.84) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL1801454 | 0.78 | CHUK (0.75) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL1798775 | 0.77 | CHUK (0.71) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL12653117 | 0.77 | CHUK (0.66) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL30342072 | 0.76 | CHUK (1.00) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL30492167 | 0.76 | CHUK (1.00) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL30039188 | 0.76 | CHUK (1.00) | CHUKICOSLGICOSIKBKBTYK2 | |
| SCHEMBL1420073 | 0.76 | CHUK (1.00) | CHUKICOSLGICOSIKBKBTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611134-A1 | BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004092167-A1 | BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-10-28 | — | — | WO | disclosed |