Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11730856 | 0.84 | MAPT (0.50) | KMT2AMEN1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL29105518 | 0.84 | SMN1; SMN2 (0.56) | KMT2AMEN1MAPTHPGDABCC8 | |
| SCHEMBL11730178 | 0.76 | NPBWR1 (0.51) | KMT2AMEN1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL21683243 | 0.71 | POLB (0.61) | KMT2AMEN1MAPTHPGDABCC8 | |
| SCHEMBL1260158 | 0.71 | MAPT (0.45) | KMT2AMEN1MAPTHPGDABCC8 | |
| SCHEMBL9555768 | 0.70 | MAPT (0.50) | KMT2AMEN1MAPTHPGDABCC1 | |
| SCHEMBL11624251 | 0.69 | HPGD (0.50) | KMT2AMEN1MAPTHPGDABCC8 | |
| SCHEMBL11276224 | 0.68 | MAPK14 (0.57) | KMT2AHPGDSMN1; SMN2KDM4ENPSR1 | |
| SCHEMBL11268832 | 0.66 | MAPK11 (0.59) | KMT2AMEN1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL5242265 | 0.66 | KMT2A (0.49) | KMT2AMEN1MAPTHPGDABCC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613612-A2 | BIOREDUCTIVELY-ACTIVATED PRODRUGS | Angiogene Pharmaceuticals Limited (GB) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004085421-A2 | BIOREDUCTIVELY-ACTIVATED PRODRUGS | ANGIOGENE PHARMACEUTICALS LIMITED (GB) | 2004-10-07 | — | — | WO | disclosed |