Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517086 | 0.84 | LMNA (0.64) | POLBLMNATAAR1MAPTKDM4E | |
| SCHEMBL5766530 | 0.71 | KMT2A (0.50) | LMNAMAPTKDM4EKMT2AHPGD | |
| SCHEMBL29030026 | 0.71 | CYP3A4 (0.52) | POLBLMNATAAR1MAPTKDM4E | |
| SCHEMBL1260158 | 0.71 | MAPT (0.45) | LMNATAAR1MAPTKMT2AHPGD | |
| SCHEMBL4265706 | 0.71 | TAAR1 (0.50) | LMNATAAR1MAPTCYP3A4KMT2A | |
| SCHEMBL29105518 | 0.70 | SMN1; SMN2 (0.56) | POLBMAPTKDM4EKMT2AHPGD | |
| SCHEMBL11730856 | 0.70 | MAPT (0.50) | POLBLMNAMAPTKMT2AHPGD | |
| SCHEMBL11453607 | 0.70 | TAAR1 (1.00) | POLBLMNATAAR1MAPTKDM4E | |
| SCHEMBL11062732 | 0.70 | KMT2A (0.54) | POLBLMNATAAR1MAPTKMT2A | |
| SCHEMBL11453608 | 0.70 | TAAR1 (1.00) | POLBLMNATAAR1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113271939-B | Imidazole tetrazine compounds | 伊利诺伊大学董事会 | 2025-03-07 | — | — | CN | disclosed |
| US-20250066371-A1 | FLUOROALKOXYALKYLENE-DIHYDROIMIDAZO[5,1-D]TETRAZINONE COMPOUNDS AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | MODIFI BIOSCIENCES, INC. | 2025-02-27 | — | — | US | disclosed |
| US-12234240-B2 | Substituted imidazo[5,1-d][1,2,3,5]tetrazines for the treatment of cancer | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2025-02-25 | — | — | US | disclosed |
| WO-2025034537-A1 | FLUOROALKOXYALKYLENE-DIHYDROIMIDAZO[5,1-D]TETRAZINONE COMPOUNDS AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | MODIFI BIOSCIENCES, INC. (US) | 2025-02-13 | — | — | WO | disclosed |
| US-20240124462-A9 | SUBSTITUTED IMIDAZO[5,1-d][1,2,3,5]TETRAZINES FOR THE TREATMENT OF CANCER | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2024-04-18 | — | — | US | disclosed |
| US-20230183252-A1 | SUBSTITUTED IMIDAZO[5,1-d][1,2,3,5]TETRAZINES FOR THE TREATMENT OF CANCER | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2023-06-15 | — | — | US | disclosed |
| US-20230183252-A1 | SUBSTITUTED IMIDAZO[5,1-d][1,2,3,5]TETRAZINES FOR THE TREATMENT OF CANCER | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2023-06-15 | — | — | US | disclosed |
| US-20210315886-A1 | IMIDAZOTETRAZINE COMPOUNDS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-10-14 | — | — | US | disclosed |
| CN-113271939-A | Imidazole tetrazine compounds | 伊利诺伊大学董事会 | 2021-08-17 | — | — | CN | disclosed |
| EP-3833342-A1 | IMIDAZOTETRAZINE COMPOUNDS | The Board of Trustees of the University of Illinois (US) | 2021-06-16 | — | — | EP | disclosed |
| US-20210002286-A1 | IMIDAZOTETRAZINE COMPOUNDS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-01-07 | — | — | US | disclosed |
| WO-2020033880-A1 | IMIDAZOTETRAZINE COMPOUNDS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2020-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250066371-A1 | FLUOROALKOXYALKYLENE-DIHYDROIMIDAZO[5,1-D]TETRAZINONE COMPOUNDS AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | PKD1, APC, VHL | POLB 2091/4885LMNA 1603/4885TAAR1 963/4885 |
| US-20230183252-A1 | SUBSTITUTED IMIDAZO[5,1-d][1,2,3,5]TETRAZINES FOR THE TREATMENT OF CANCER | MCL1, IDH1, IDH2 | POLB 1506/4885LMNA 3493/4885TAAR1 1679/4885 |
| US-20240124462-A9 | SUBSTITUTED IMIDAZO[5,1-d][1,2,3,5]TETRAZINES FOR THE TREATMENT OF CANCER | MCL1, IDH1, IDH2 | POLB 1506/4885LMNA 3493/4885TAAR1 1679/4885 |
| US-12234240-B2 | Substituted imidazo[5,1-d][1,2,3,5]tetrazines for the treatment of cancer | MCL1, IDH1, IDH2 | POLB 1506/4885LMNA 3493/4885TAAR1 1679/4885 |
| US-20210002286-A1 | IMIDAZOTETRAZINE COMPOUNDS | MCL1, IDH1, IDH2 | POLB 1551/4885LMNA 3448/4885TAAR1 3545/4885 |
| US-20210315886-A1 | IMIDAZOTETRAZINE COMPOUNDS | MCL1, IDH1, IDH2 | POLB 1551/4885LMNA 3448/4885TAAR1 3545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.