Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 12/20 | 0.63 |
| ▸ | ABCC8 | Q09428 | 12/20 | 0.63 |
| ▸ | KCNJ11 | Q14654 | 12/20 | 0.63 |
| ▸ | KCNJ8 | Q15842 | 12/20 | 0.63 |
| ▸ | PDK1 | Q15118 | 8/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 8/20 | 0.47 |
| ▸ | PDK3 | Q15120 | 8/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 8/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766413 | 0.90 | ABCC9 (0.57) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5765533 | 0.86 | ABCC9 (0.48) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5767979 | 0.83 | ABCC9 (0.57) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL7829732 | 0.82 | ABCC9 (0.58) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL7832380 | 0.81 | ABCC9 (0.67) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5766571 | 0.80 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5765103 | 0.80 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5764774 | 0.79 | ABCC9 (0.52) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5767101 | 0.79 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL5766323 | 0.79 | PDK1 (0.49) | ABCC9ABCC8KCNJ11KCNJ8PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979821-B1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2006-09-13 | — | — | EP | disclosed |
| US-6211227-B1 | SULFUR CONTAINING TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0979821-A1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-02-16 | — | — | EP | disclosed |