Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 14/20 | 0.51 |
| ▸ | CCR5 | P51681 | 6/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | UBE2M | P61081 | 3/20 | 0.49 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4416862 | 0.87 | CCR2 (0.64) | CCR2CCR5KCNH2 | |
| SCHEMBL3733740 | 0.86 | CCR2 (0.68) | CCR2CCR5KCNH2CHRM2CHRM4 | |
| SCHEMBL3733738 | 0.86 | CCR2 (0.68) | CCR2CCR5KCNH2CHRM2CHRM4 | |
| SCHEMBL3733734 | 0.86 | CCR2 (0.68) | CCR2CCR5KCNH2CHRM2CHRM4 | |
| SCHEMBL4427345 | 0.84 | CCR2 (0.55) | CCR2CCR5KCNH2 | |
| SCHEMBL5767886 | 0.81 | CCR2 (0.61) | CCR2CCR5KCNH2 | |
| SCHEMBL5767261 | 0.78 | CCR2 (0.77) | CCR2CCR5KCNH2 | |
| SCHEMBL5769129 | 0.77 | CCR2 (0.63) | CCR2CCR5KCNH2MEN1KMT2A | |
| SCHEMBL5768595 | 0.75 | CCR2 (0.61) | CCR2CCR5KCNH2MEN1KMT2A | |
| SCHEMBL5770110 | 0.75 | CCR2 (0.61) | CCR2CCR5KCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656345-A1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Company (US) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005021500-A1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-03-10 | — | — | WO | disclosed |