Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.39 |
| ▸ | SRC | P12931 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 3/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766162 | 0.91 | KDR (0.46) | FGFR1KDRKDM4EALDH1A1MAPT | |
| SCHEMBL5767694 | 0.90 | MAPT (0.42) | FGFR1SRCKDRKDM4EALDH1A1 | |
| SCHEMBL5767404 | 0.89 | FGFR1 (0.42) | BRAFFGFR1SRCKDRMIF | |
| SCHEMBL5767103 | 0.89 | BRAF (0.40) | BRAFFGFR1SRCKDRKDM4E | |
| SCHEMBL5767448 | 0.87 | FGFR1 (0.45) | BRAFFGFR1SRCKDRMIF | |
| SCHEMBL5767029 | 0.87 | MIF (0.48) | BRAFFGFR1SRCKDRMIF | |
| SCHEMBL5766820 | 0.85 | FGFR1 (0.54) | BRAFFGFR1SRCKDRMIF | |
| SCHEMBL5764733 | 0.85 | KDR (0.45) | FGFR1SRCKDRNTRK1FLT3 | |
| SCHEMBL5764876 | 0.85 | IRAK4 (0.40) | FGFR1SRCKDRKDM4EALDH1A1 | |
| SCHEMBL5767666 | 0.83 | CHKA (0.41) | FGFR1SRCKDRHPGDNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235825-B1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PROD INC (US) | 2006-01-25 | — | — | EP | claimed |