Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 4/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | SRC | P12931 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764733 | 0.93 | KDR (0.45) | KDRTLR7FGFR1SRCHRH3 | |
| SCHEMBL5764607 | 0.91 | FGFR1 (0.47) | KDRTLR7FGFR1SRCHRH3 | |
| SCHEMBL5767801 | 0.89 | NTRK1 (0.44) | KDRMAP3K11TLR7FGFR1SRC | |
| SCHEMBL5765955 | 0.87 | LTA4H (0.36) | KDRMAP3K11FGFR1SRCNTRK1 | |
| SCHEMBL5765675 | 0.87 | NTRK1 (0.38) | KDRMAP3K11FGFR1SRCNTRK1 | |
| SCHEMBL5766984 | 0.87 | NTRK1 (0.38) | KDRMAP3K11FGFR1SRCNTRK1 | |
| SCHEMBL5767363 | 0.86 | LTA4H (0.39) | KDRMAP3K11RAB9AFGFR1HRH3 | |
| SCHEMBL5768958 | 0.86 | LTA4H (0.39) | KDRMAP3K11RAB9AFGFR1HRH3 | |
| SCHEMBL5765132 | 0.86 | MAP3K11 (0.41) | CHKAMAP3K11MERTKTLR7NPC1 | |
| SCHEMBL5767404 | 0.85 | FGFR1 (0.42) | KDRMAP3K11FGFR1SRCNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235825-B1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PROD INC (US) | 2006-01-25 | — | — | EP | claimed |