Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 7/20 | 0.45 |
| ▸ | SRC | P12931 | 4/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | MIF | P14174 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766820 | 0.91 | FGFR1 (0.54) | FGFR1SRCKDRBRAFMIF | |
| SCHEMBL5767156 | 0.91 | KDR (0.46) | FGFR1SRCKDRATM | |
| SCHEMBL5766182 | 0.90 | FGFR1 (0.43) | FGFR1SRCKDRCDK2 | |
| SCHEMBL5767404 | 0.89 | FGFR1 (0.42) | FGFR1SRCKDRBRAFMIF | |
| SCHEMBL5767045 | 0.87 | BRAF (0.39) | FGFR1SRCKDRBRAFMIF | |
| SCHEMBL5767029 | 0.87 | MIF (0.48) | FGFR1SRCKDRBRAFMIF | |
| SCHEMBL5764733 | 0.85 | KDR (0.45) | FGFR1SRCKDRTLR7HRH3 | |
| SCHEMBL5764566 | 0.85 | FGFR1 (0.43) | FGFR1SRCKDRTLR7CCNE1 | |
| SCHEMBL5767103 | 0.83 | BRAF (0.40) | FGFR1SRCKDRBRAFMIF | |
| SCHEMBL5767666 | 0.83 | CHKA (0.41) | FGFR1SRCKDRTLR7HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235825-B1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PROD INC (US) | 2006-01-25 | — | — | EP | claimed |