SCHEMBL5767274

SCHEMBL5767274

SC(c1ccccc1C1CCCCN1)c1cccc2ccccc12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACP3 P15309 1/20 0.36
CYP2D6 P10635 4/20 0.35
CYP1A2 P05177 3/20 0.35
CYP2C19 P33261 3/20 0.35
CYP2C9 P11712 2/20 0.35
ALDH1A1 P00352 1/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
POLB P06746 1/20 0.35
CHRNB2 P17787 1/20 0.35
CHRNA7 P36544 1/20 0.35
CHRNA4 P43681 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CYP2A6 P11509 1/20 0.35
NR1H4 Q96RI1 1/20 0.34
ADRA2A P08913 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
IKBKB O14920 1/20 0.33
SCN9A Q15858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9634176 0.81 KDM1A (0.43) CYP2D6CYP1A2CYP2C19CYP2C9MEN1
SCHEMBL25973017 0.77 SCN9A (0.46) CYP2D6MEN1KMT2ACHRNB2CHRNA7
SCHEMBL4149119 0.77 SCN9A (0.46) CYP2D6MEN1KMT2ACHRNB2CHRNA7
SCHEMBL25243180 0.74 MEN1 (0.41) CYP2D6CYP1A2CYP2C19CYP2C9MEN1
SCHEMBL21566690 0.74 MEN1 (0.41) CYP2D6CYP1A2CYP2C19CYP2C9MEN1
SCHEMBL19171120 0.74 MEN1 (0.41) CYP2D6CYP1A2CYP2C19CYP2C9MEN1
SCHEMBL6806512 0.73 MAPT (0.41) CYP2D6CYP1A2CYP2C19CYP2C9ALDH1A1
SCHEMBL12435076 0.71 CYP2D6 (0.58) CYP2D6CYP1A2CYP2C19ALDH1A1MEN1
SCHEMBL23057911 0.69 TAAR1 (0.43) MEN1KMT2ACHRNB2CHRNA7CHRNA4
SCHEMBL29589340 0.69 TAAR1 (0.43) MEN1KMT2ACHRNB2CHRNA7CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1644337-A1 MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF Gene Logic, Inc. (US) 2006-04-12 EP disclosed
WO-2005121100-A1 MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF GENE LOGIC INC. (US) 2005-12-22 WO disclosed