Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634176 | 0.84 | KDM1A (0.43) | NR1H4IKBKBCYP2D6MEN1CYP1A2 | |
| SCHEMBL25973017 | 0.79 | SCN9A (0.46) | NR1H4CYP2D6MEN1KMT2ACHRNB2 | |
| SCHEMBL4149119 | 0.79 | SCN9A (0.46) | NR1H4CYP2D6MEN1KMT2ACHRNB2 | |
| SCHEMBL2097203 | 0.78 | IDO1 (0.43) | IKBKBCYP2D6MEN1CYP1A2CYP2C19 | |
| SCHEMBL11003369 | 0.77 | PTPN22 (0.48) | MAPTKDM4EALOX12PTPN22ALDH1A1 | |
| SCHEMBL28905130 | 0.77 | NR1H4 (0.39) | NR1H4CYP2D6MEN1KMT2ACHRNB2 | |
| SCHEMBL11002817 | 0.76 | ALDH1A1 (0.48) | MAPTKDM4EALOX12PTPN22ALDH1A1 | |
| Hydrochloric Acid SCHEMBL20914773 | 0.74 | CYP1A2 (0.41) | ALDH1A1CYP2D6MEN1CYP1A2CYP2C19 | |
| SCHEMBL10653671 | 0.74 | IKBKB (0.48) | IKBKBCYP2D6MEN1CYP1A2CYP2C19 | |
| SCHEMBL5767274 | 0.73 | ACP3 (0.36) | NR1H4IKBKBALDH1A1CYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040072865-A1 | Aryl piperidine derivatives as inducers of ldl-receptor expression | SMITHKLINE BEECHAM CORPORATION | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072865-A1 | Aryl piperidine derivatives as inducers of ldl-receptor expression | NR1H2, NR1H3, NR1H4 | MAPT 4646/4885KDM4E 2193/4885ALOX12 1659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.