Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | TEK | Q02763 | 5/20 | 0.34 |
| ▸ | KDR | P35968 | 5/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5767192 | 0.91 | RIPK1 (0.40) | PDE10ACSNK1A1CSNK1DGSK3BCSNK1G2 | |
| SCHEMBL5447181 | 0.78 | RAF1 (0.44) | PDE10ACSNK1A1CSNK1DGSK3BCSNK1G2 | |
| SCHEMBL5454095 | 0.77 | PDE10A (0.38) | PDE10ACSNK1A1CSNK1DGSK3BCSNK1G2 | |
| SCHEMBL4161466 | 0.75 | KDR (0.53) | PDE10ACSNK1A1CSNK1DGSK3BCSNK1G2 | |
| SCHEMBL5454092 | 0.71 | PDE10A (0.42) | PDE10ACSNK1A1CSNK1DGSK3BCSNK1G2 | |
| SCHEMBL5456254 | 0.71 | RAF1 (0.44) | PDE10ACSNK1A1CSNK1DGSK3BCSNK1G2 | |
| SCHEMBL4168762 | 0.71 | RAF1 (0.38) | PDE10ACSNK1A1CSNK1DGSK3BCSNK1G2 | |
| SCHEMBL4159414 | 0.69 | RAB9A (0.42) | PDE10ACSNK1A1CSNK1DGSK3BCSNK1G2 | |
| SCHEMBL5449925 | 0.68 | KDR (0.49) | PDE10ACSNK1A1CSNK1DGSK3BCSNK1G2 | |
| SCHEMBL5459650 | 0.68 | RAF1 (0.43) | PDE10ACSNK1A1CSNK1DGSK3BCSNK1G2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656377-A1 | AMINOBENZIMIDAZOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-05-17 | — | — | EP | claimed |
| WO-2005019216-A1 | AMINOBENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-03-03 | — | — | WO | claimed |