Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5768676 | 0.89 | NPSR1 (0.39) | SMN1; SMN2MAPTHTTHSD11B1LMNA | |
| SCHEMBL5768202 | 0.86 | HSD11B1 (0.48) | SMN1; SMN2MAPTHTTHSD11B1LMNA | |
| SCHEMBL17050424 | 0.72 | NPC1 (0.41) | SMN1; SMN2MAPTHTTHSD11B1LMNA | |
| SCHEMBL3319917 | 0.72 | HSD11B1 (0.41) | SMN1; SMN2MAPTHTTHSD11B1LMNA | |
| SCHEMBL3739983 | 0.68 | HDAC4 (0.57) | SMN1; SMN2MAPTHTTLMNANPSR1 | |
| SCHEMBL617951 | 0.66 | NPC1 (0.44) | SMN1; SMN2MAPTHTTHSD11B1LMNA | |
| SCHEMBL22891112 | 0.66 | NPC1 (0.56) | SMN1; SMN2MAPTHTTHSD11B1LMNA | |
| SCHEMBL5344604 | 0.65 | MAPT (0.53) | SMN1; SMN2MAPTHTTHSD11B1LMNA | |
| SCHEMBL12210687 | 0.63 | NPC1 (0.44) | SMN1; SMN2MAPTHTTHSD11B1LMNA | |
| SCHEMBL3321298 | 0.63 | RAB9A (0.42) | SMN1; SMN2MAPTHTTLMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675844-A1 | PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE | Sterix Limited (GB) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005042513-A1 | PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE | STERIX LIMITED (GB) | 2005-05-12 | — | — | WO | disclosed |