SCHEMBL5768068

SCHEMBL5768068

Cn1cnc2c(=O)nc(SCc3csc4ccc(Cl)cc34)n(-c3ccc(C(F)(F)F)cc3)c21

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
ABCB1 P08183 1/20 0.36
LMNA P02545 2/20 0.34
MAPT P10636 1/20 0.34
UBE2M P61081 1/20 0.34
DCUN1D1 Q96GG9 1/20 0.34
ALDH1A2 O94788 1/20 0.33
ALDH1A3 P47895 1/20 0.33
KEAP1 Q14145 1/20 0.32
NFE2L2 Q16236 1/20 0.32
CYP2A6 P11509 1/20 0.32
ANXA2 P07355 1/20 0.32
S100A10 P60903 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5769812 0.93 KDM1A (0.40) KDM1AABCB1UBE2MDCUN1D1ALDH1A2
SCHEMBL5768472 0.91 KDM1A (0.36) KDM1AL3MBTL1ABCB1MAPTUBE2M
SCHEMBL5434800 0.87 ALDH1A2 (0.40) KDM1AL3MBTL1ABCB1LMNAMAPT
SCHEMBL5769348 0.82 KDM1A (0.38) KDM1AABCB1UBE2MDCUN1D1ALDH1A2
SCHEMBL5770177 0.81 KDM1A (0.36) KDM1AABCB1MAPTUBE2MDCUN1D1
SCHEMBL5765579 0.80 EPHX1 (0.38) KDM1AABCB1LMNAKEAP1NFE2L2
SCHEMBL5426588 0.79 ALDH1A2 (0.43) KDM1AABCB1ALDH1A2ALDH1A3
SCHEMBL5428614 0.78 PTGS2 (0.38)
SCHEMBL5438197 0.78 ALDH1A2 (0.39) KDM1AABCB1ALDH1A2ALDH1A3
SCHEMBL5429211 0.74 ALDH1A2 (0.41) KDM1AABCB1ALDH1A2ALDH1A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1687306-A1 BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) MERCK SHARP & DOHME LTD. (GB) 2006-08-09 EP claimed
WO-2005049613-A1 BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) MERCK SHARP & DOHME LIMITED (GB) 2005-06-02 WO claimed