Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | DTYMK | P23919 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719811 | 0.80 | MTNR1A (0.51) | ALDH1A1 | |
| SCHEMBL5768646 | 0.79 | MTNR1A (0.47) | ALDH1A1 | |
| SCHEMBL3050216 | 0.78 | LIPG (0.51) | ESR2CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL20434858 | 0.77 | ESR2 (0.39) | ESR2NAMPTNR1H2LMNATP53 | |
| SCHEMBL13056761 | 0.76 | PARP1 (0.41) | ALDH1A1 | |
| SCHEMBL21577586 | 0.75 | MAPT (0.41) | ESR2NAMPTNR1H2ALDH1A1LIPG | |
| SCHEMBL8363597 | 0.75 | NAMPT (0.38) | NAMPTNR1H2LMNATP53POLB | |
| SCHEMBL2018775 | 0.75 | POLB (0.51) | LMNAPOLBTHRB | |
| SCHEMBL2261638 | 0.74 | ESR2 (0.45) | ESR2NAMPTNR1H2LMNATP53 | |
| SCHEMBL10234454 | 0.73 | TMEM97 (0.44) | LIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483265-B1 | PURINE DERIVATIVES AS KINASE INHIBITORS | LILLY CO ELI (US) | 2006-11-22 | — | — | EP | disclosed |