Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13224711 | 0.82 | HSD11B1 (0.46) | HSD11B1HSD17B10POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL10089757 | 0.76 | LMNA (0.64) | HSD11B1HSD17B10POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL1049510 | 0.74 | SMN1; SMN2 (0.61) | HSD17B10POLBALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL29361355 | 0.74 | SMN1; SMN2 (0.61) | HSD17B10POLBALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5348047 | 0.73 | HSD17B10 (0.51) | HSD11B1HSD17B10CYP3A4ALDH1A1SMN1; SMN2 | |
| Propane SCHEMBL28083723 | 0.73 | SMN1; SMN2 (0.56) | HSD17B10POLBALDH1A1SMN1; SMN2NPC1 | |
| Iodomethane SCHEMBL28083731 | 0.71 | SMN1; SMN2 (0.57) | HSD17B10POLBALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL8408901 | 0.71 | SMN1; SMN2 (0.48) | HSD17B10POLBALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL617597 | 0.71 | HSD11B1 (0.65) | HSD11B1ALDH1A1LMNAHTTPKM | |
| SCHEMBL13156344 | 0.70 | HSD17B10 (0.70) | HSD17B10POLBALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| EP-1675844-A1 | PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE | Sterix Limited (GB) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005042513-A1 | PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE | STERIX LIMITED (GB) | 2005-05-12 | — | — | WO | disclosed |