Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.41 |
| ▸ | CHRNG | P07510 | 1/20 | 0.41 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CHRND | Q07001 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4409738 | 0.93 | KDM4E (0.50) | GPR119IRAK4KDM4EEGLN2AR | |
| Hydrochloric Acid SCHEMBL6824751 | 0.86 | CHRNB2 (0.58) | GPR119IRAK4KDM4EEGLN2AR | |
| SCHEMBL25888624 | 0.85 | GPR119 (0.47) | GPR119IRAK4KDM4EEGLN2AR | |
| SCHEMBL31421094 | 0.81 | USP30 (0.51) | GPR119KDM4E | |
| SCHEMBL5769158 | 0.81 | KDM4E (0.50) | GPR119KDM4EMAPT | |
| SCHEMBL15601524 | 0.81 | GPR119 (0.54) | GPR119KDM4EEGLN2AR | |
| SCHEMBL30976364 | 0.80 | GPR119 (0.52) | GPR119IRAK4EGLN2 | |
| Hydrochloric Acid SCHEMBL28007262 | 0.80 | GPR119 (0.53) | GPR119KDM4EEGLN2AR | |
| SCHEMBL17629880 | 0.78 | GPR119 (0.54) | GPR119IRAK4KDM4EEGLN2MAPT | |
| SCHEMBL20346929 | 0.78 | GPR119 (0.58) | GPR119IRAK4KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648872-A2 | ARYL FUSED AZAPOLYCYCLIC COMPOUNDS | Pfizer Products Inc. (US) | 2006-04-26 | — | — | EP | claimed |
| WO-2005007630-A2 | ARYL FUSED AZAPOLYCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-01-27 | — | — | WO | claimed |
| US-20050020616-A1 | Aryl fused azapolycyclic compounds | PFIZER INC | 2005-01-27 | — | — | US | claimed |
| US-20050020616-A1 | Aryl fused azapolycyclic compounds | PFIZER INC | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020616-A1 | Aryl fused azapolycyclic compounds | GRIN2C, GRIN2A, GRIN2B | GPR119 440/4885IRAK4 3156/4885KDM4E 783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.