Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 4/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2127290 | 0.98 | DNM1 (0.46) | DNM1CA1CA12CA2CA9 | |
| SCHEMBL12669289 | 0.98 | DNM1 (0.46) | DNM1CA1CA12CA2CA9 | |
| SCHEMBL17676601 | 0.88 | DNM1 (0.42) | DNM1CA1CA12CA2CA9 | |
| SCHEMBL17676553 | 0.88 | DNM1 (0.42) | DNM1CA1CA12CA2CA9 | |
| SCHEMBL8654027 | 0.87 | CA1 (0.43) | CA1CA12CA2CA9 | |
| SCHEMBL15746839 | 0.86 | DNM1 (0.39) | DNM1CA1CA12CA2CA9 | |
| SCHEMBL10312297 | 0.83 | CA1 (0.52) | CA1CA12CA2CA9 | |
| SCHEMBL15648362 | 0.81 | GPR84 (0.43) | TSHR | |
| SCHEMBL16204456 | 0.81 | DNM1 (0.33) | DNM1CA1CA12CA2CA9 | |
| SCHEMBL2126416 | 0.80 | DNM1 (0.48) | DNM1CA1CA12CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694298-A2 | METHOD FOR SELECTING CATIONIC OR ANIONIC LIPOSOMES FOR TREATMENT OF A MUCOSA MEMBRANE, AND KIT COMPRISING THE SAME | Yissum Research Development Company, of The Hebrew University of Jerusalem (IL) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005041932-A2 | METHOD FOR SELECTING CATIONIC OR ANIONIC LIPOSOMES FOR TREATMENT OF A MUCOSA MEMBRANE, AND KIT COMPRISING THE SAME | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2005-05-12 | — | — | WO | disclosed |