Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 16/20 | 0.58 |
| ▸ | GABRG2 | P18507 | 16/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 16/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 15/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2659067 | 0.91 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7225940 | 0.76 | GABRA1 (0.62) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6216228 | 0.75 | GABRA1 (0.63) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5769623 | 0.75 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5769488 | 0.73 | GABRA1 (0.85) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5771561 | 0.70 | GABRA1 (0.78) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5770759 | 0.70 | GABRG2 (0.38) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| Trifluoroacetic Acid SCHEMBL7233976 | 0.69 | GABRA1 (0.58) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5768855 | 0.64 | GABRA1 (0.77) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6217439 | 0.64 | GABRA1 (0.68) | GABRA1GABRG2GABRB3GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383768-B1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-09-06 | — | — | EP | disclosed |