Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 15/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 15/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 15/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 13/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773850 | 0.85 | GABRA1 (0.51) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5770060 | 0.79 | KDM4E (0.48) | GABRA1GABRG2GABRB3GABRA3TGFBR1 | |
| SCHEMBL5261894 | 0.73 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL16678705 | 0.68 | PKM (0.51) | TGFBR1 | |
| SCHEMBL5773757 | 0.68 | GABRA1 (0.64) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5770436 | 0.68 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5770491 | 0.67 | GABRA1 (0.68) | GABRA1GABRG2GABRB3GABRA3TGFBR1 | |
| SCHEMBL5770368 | 0.66 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2657365 | 0.66 | GABRA1 (0.67) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5771410 | 0.66 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383768-B1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-09-06 | — | — | EP | disclosed |