Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 19/20 | 0.66 |
| ▸ | F13A1 | P00488 | 1/20 | 0.56 |
| ▸ | TGM2 | P21980 | 1/20 | 0.56 |
| ▸ | TGM1 | P22735 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5806971 | 0.96 | HSD11B1 (0.63) | HSD11B1F13A1TGM2TGM1 | |
| SCHEMBL6356222 | 0.83 | HSD11B1 (0.50) | HSD11B1 | |
| SCHEMBL6350461 | 0.83 | SMN1; SMN2 (0.56) | HSD11B1 | |
| SCHEMBL5750293 | 0.81 | PPARD (0.49) | — | |
| SCHEMBL5772894 | 0.81 | HSD11B1 (0.62) | HSD11B1 | |
| SCHEMBL5770474 | 0.80 | KDM4E (0.63) | HSD11B1 | |
| SCHEMBL5745816 | 0.80 | LMNA (0.45) | HSD11B1F13A1TGM2TGM1 | |
| SCHEMBL19248151 | 0.80 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL6356232 | 0.79 | PTGDR (0.48) | — | |
| SCHEMBL5750620 | 0.79 | PTGDR (0.52) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735280-A1 | ARYL SULFONAMIDE AND SULFONYL COMPOUNDS AS MODULATORS OF PPAR AND METHODS OF TREATING METABOLIC DISORDERS | Kalypsys, Inc. (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005115983-A1 | ARYL SULFONAMIDE AND SULFONYL COMPOUNDS AS MODULATORS OF PPAR AND METHODS OF TREATING METABOLIC DISORDERS | KALYPSYS, INC. (US) | 2005-12-08 | — | — | WO | disclosed |