Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TERT | O14746 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746662 | 0.93 | HTR1B (0.51) | HTR1BHTR1DALDH1A1KIF11HTR2A | |
| SCHEMBL5745080 | 0.91 | HTR1B (0.51) | HTR1BHTR1DALDH1A1TSHRKIF11 | |
| SCHEMBL5770346 | 0.86 | HTR1B (0.60) | HTR1BTERTKIF11MPO | |
| SCHEMBL5748283 | 0.84 | HTR1B (0.52) | HTR1BHTR1DALDH1A1TSHRKIF11 | |
| SCHEMBL898343 | 0.83 | KDM4E (0.50) | HTR1BALDH1A1TSHRKIF11KDM4E | |
| SCHEMBL27955668 | 0.83 | KDM4E (0.54) | ALDH1A1TSHRKIF11KDM4ESMN1; SMN2 | |
| SCHEMBL28194700 | 0.82 | KDM4E (0.49) | HTR1BALDH1A1TSHRKIF11KDM4E | |
| SCHEMBL5746054 | 0.82 | HTR1B (0.59) | HTR1BHTR1DALDH1A1KIF11KDM4E | |
| SCHEMBL11806570 | 0.80 | HTR1B (0.61) | HTR1BHTR1DALDH1A1TSHRHTT | |
| SCHEMBL5018077 | 0.79 | KIF11 (0.53) | ALDH1A1TSHRKIF11KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711463-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2006-10-18 | — | — | EP | claimed |
| WO-2005077899-A2 | AMINO-SUBSTITUTED TRICYCLIC DERIVATIVES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-08-25 | — | — | WO | claimed |