Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5931015 | 1.00 | HPGD (0.50) | HPGDRECQLGPR119EPHX1USP2 | |
| SCHEMBL1722011 | 0.90 | HPGD (0.50) | HPGDRECQLGPR119EPHX1USP2 | |
| SCHEMBL1722010 | 0.90 | HPGD (0.50) | HPGDRECQLGPR119EPHX1USP2 | |
| SCHEMBL18586916 | 0.84 | HPGD (0.54) | HPGDRECQLGPR119EPHX1USP2 | |
| SCHEMBL18586918 | 0.84 | HPGD (0.54) | HPGDRECQLGPR119EPHX1USP2 | |
| SCHEMBL20128945 | 0.83 | HPGD (0.45) | HPGDRECQLGPR119EPHX1USP2 | |
| SCHEMBL20519800 | 0.81 | HPGD (0.50) | HPGDRECQLGPR119EPHX1USP2 | |
| SCHEMBL20519803 | 0.81 | HPGD (0.50) | HPGDRECQLGPR119EPHX1USP2 | |
| SCHEMBL22955531 | 0.81 | HPGD (0.50) | HPGDRECQLGPR119EPHX1USP2 | |
| SCHEMBL25528906 | 0.80 | HPGD (0.53) | HPGDRECQLGPR119EPHX1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053214-B2 | β-sheet mimetics and composition and methods relating thereto | MYRIAD GENETICS, INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20060084653-A1 | Beta-sheet mimetics and composition and methods relating thereto | MYRIAD GENETICS, INCORPORATED (US) | 2006-04-20 | — | — | US | disclosed |
| EP-1482941-A4 | BETA-SHEET MIMETICS AND COMPOSITION AND METHODS RELATING THERETO | MYRIAD GENETICS INC (US) | 2006-04-12 | — | — | EP | disclosed |
| EP-1482941-A1 | BETA-SHEET MIMETICS AND COMPOSITION AND METHODS RELATING THERETO | Myriad Pharmaceuticals, Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| US-20040014763-A1 | beta-sheet mimetics and composition and methods relating thereto | MYRIAD PHARMACEUTICALS, INC. (US) | 2004-01-22 | — | — | US | disclosed |
| WO-2003068237-A1 | BETA-SHEET MIMETICS AND COMPOSITION AND METHODS RELATING THERETO | MYRIAD GENETICS, INC. (US) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014763-A1 | beta-sheet mimetics and composition and methods relating thereto | TPSAB1, TPSB2, TPSD1 | HPGD 2936/4885RECQL 526/4885GPR119 1083/4885 |
| US-20060084653-A1 | Beta-sheet mimetics and composition and methods relating thereto | TPSAB1, TPSB2, TPSD1 | HPGD 2457/4885RECQL 439/4885GPR119 886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.