Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 16/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 16/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 16/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 14/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.50 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5770846 | 0.93 | GABRA1 (0.56) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL7233506 | 0.83 | GABRG2 (0.62) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5769518 | 0.81 | GABRA1 (0.54) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6220198 | 0.81 | GABRA1 (0.62) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5767906 | 0.79 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2658604 | 0.79 | GABRA1 (0.68) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5770384 | 0.78 | GABRA1 (0.71) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL2659346 | 0.77 | GABRA1 (0.81) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6216756 | 0.76 | GABRA1 (0.64) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6216371 | 0.76 | GABRA1 (0.67) | GABRA1GABRG2GABRB3GABRA3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383768-B1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-09-06 | — | — | EP | claimed |
| EP-1383768-B1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-09-06 | — | — | EP | disclosed |