Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6697312 | 0.89 | FYN (0.38) | PDE7ANPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7499774 | 0.84 | PTGS2 (0.37) | PDE7ANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL5771902 | 0.82 | SMN1; SMN2 (0.48) | PDE7ASMN1; SMN2KDM4EMAPTLMNA | |
| SCHEMBL5770736 | 0.78 | PTGS2 (0.44) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL6691783 | 0.70 | PTGS2 (0.39) | SMN1; SMN2TP53MAPTLMNASMO | |
| SCHEMBL22095084 | 0.64 | MEN1 (0.60) | NPC1RAB9ATP53KDM4EMAPT | |
| SCHEMBL5778310 | 0.64 | POLB (0.51) | SMN1; SMN2MAPTLMNA | |
| SCHEMBL5773731 | 0.63 | PTGS2 (0.51) | SMN1; SMN2TP53KDM4EMAPTLMNA | |
| SCHEMBL5774424 | 0.62 | POLB (0.46) | SMN1; SMN2KDM4EMAPTLMNAMEN1 | |
| SCHEMBL6692596 | 0.62 | BRAF (0.40) | SMN1; SMN2MAPTMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224189-B1 | CONDENSED DIHYDROQUINOLINONE DERIVATIVES FOR INHIBITING MRP1 | LILLY CO ELI (US) | 2006-01-25 | — | — | EP | disclosed |
| US-6670373-B1 | Inhibiting resistant neoplasms where the resistance is conferred by multidrug resistance protein; N-3,4,5-trimethoxyphenyl-3-(3-azidomethyl-isoxazolo(4,5-c) -1,2-dihydro-6-chloro-quinolin-2-on-1-yl)phenylacetamide | ELI LILLY AND COMPANY | 2003-12-30 | — | — | US | disclosed |