Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMO | Q99835 | 2/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5771897 | 0.84 | PDE7A (0.39) | MAPTLMNAGAARAB9ASMN1; SMN2 | |
| SCHEMBL7499779 | 0.82 | SMN1; SMN2 (0.47) | PTGS2MAPTLMNARAB9ASMN1; SMN2 | |
| SCHEMBL5770736 | 0.80 | PTGS2 (0.44) | PTGS2MAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6697312 | 0.76 | FYN (0.38) | MAPTLMNAGAARAB9ASMN1; SMN2 | |
| SCHEMBL6691783 | 0.71 | PTGS2 (0.39) | PTGS2MAPTLMNASMN1; SMN2MEN1 | |
| SCHEMBL5773623 | 0.70 | EPAS1 (0.58) | PTGS2MAPTLMNASMN1; SMN2MEN1 | |
| SCHEMBL5771902 | 0.66 | SMN1; SMN2 (0.48) | PTGS2MAPTLMNASMN1; SMN2MEN1 | |
| SCHEMBL5773731 | 0.65 | PTGS2 (0.51) | PTGS2MAPTLMNASMN1; SMN2MEN1 | |
| SCHEMBL5778310 | 0.64 | POLB (0.51) | PTGS2MAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5774719 | 0.62 | PTGS2 (0.48) | PTGS2MAPTLMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224189-A2 | CONDENSED DIHYDROQUINOLINONE DERIVATIVES FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027116-A2 | CONDENSED DIHYDROQUINOLINONE DERIVATIVES FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2001-04-19 | — | — | WO | disclosed |