Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.88 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.88 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.88 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.65 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.62 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.62 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6591096 | 0.95 | OPRM1 (0.97) | OPRM1OPRL1OPRK1CYP2D6CYP2C9 | |
| SCHEMBL6585522 | 0.94 | OPRM1 (1.00) | OPRM1OPRL1OPRK1CYP2D6CYP2C9 | |
| SCHEMBL4921324 | 0.94 | OPRM1 (1.00) | OPRM1OPRL1OPRK1CYP2D6CYP2C9 | |
| SCHEMBL4913077 | 0.94 | OPRM1 (1.00) | OPRM1OPRL1OPRK1CYP2D6CYP2C9 | |
| SCHEMBL4922697 | 0.94 | OPRM1 (1.00) | OPRM1OPRL1OPRK1CYP2D6CYP2C9 | |
| SCHEMBL14186018 | 0.94 | OPRM1 (1.00) | OPRM1OPRL1OPRK1CYP2D6CYP2C9 | |
| SCHEMBL12204966 | 0.92 | OPRM1 (0.80) | OPRM1OPRL1OPRK1CYP2D6CYP2C9 | |
| SCHEMBL14515243 | 0.91 | OPRM1 (0.78) | OPRM1OPRL1OPRK1CYP2D6CYP2C9 | |
| SCHEMBL8976901 | 0.90 | OPRM1 (0.72) | OPRM1OPRL1OPRK1CYP2D6CYP2C9 | |
| SCHEMBL8976895 | 0.90 | OPRM1 (0.72) | OPRM1OPRL1OPRK1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180649-B1 | NERVOUS SYSTEM DISORDERS; ALZHEIMER'S, HUNTINGTON, PARKINSON DISEASE | NEROSEARCH A/S (DK) | 2001-01-30 | — | — | US | claimed |
| EP-0898568-B1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH AS (DK) | 2006-10-04 | — | — | EP | disclosed |
| US-6180649-B1 | NERVOUS SYSTEM DISORDERS; ALZHEIMER'S, HUNTINGTON, PARKINSON DISEASE | NEROSEARCH A/S (DK) | 2001-01-30 | — | — | US | disclosed |
| EP-0898568-A1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH A/S (DK) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040035-A1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH A/S (DK) | 1997-10-30 | — | — | WO | disclosed |