Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | NPY5R | Q15761 | 16/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5773195 | 0.99 | MEN1 (0.65) | MEN1KMT2ANPY5RSMN1; SMN2PIK3CA | |
| SCHEMBL12105217 | 0.78 | CHRM4 (0.42) | MEN1KMT2ANPY5RPIK3CAMTOR | |
| SCHEMBL12994831 | 0.77 | PIK3CA (0.65) | MEN1KMT2ANPY5RPIK3CAMTOR | |
| SCHEMBL5773316 | 0.75 | NPY5R (1.00) | MEN1KMT2ANPY5RSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5774363 | 0.74 | NPY5R (0.97) | MEN1KMT2ANPY5RSMN1; SMN2 | |
| SCHEMBL5771955 | 0.74 | MEN1 (0.51) | MEN1KMT2ANPY5RSMN1; SMN2 | |
| SCHEMBL12105218 | 0.74 | PDPK1 (0.42) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL602251 | 0.73 | HRH4 (0.50) | MEN1KMT2APIK3CAMTOR | |
| Hydrochloric Acid SCHEMBL5776500 | 0.73 | MEN1 (0.50) | MEN1KMT2ANPY5RSMN1; SMN2 | |
| SCHEMBL5772334 | 0.73 | NPY5R (0.78) | MEN1KMT2ANPY5RSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | disclosed |