Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5776500 | 0.99 | MEN1 (0.50) | MEN1KMT2ANPY5RSMN1; SMN2KDM4E | |
| SCHEMBL5773830 | 0.77 | NPY5R (0.61) | MEN1KMT2ANPY5RSMN1; SMN2KDM4E | |
| SCHEMBL5775005 | 0.75 | NPY5R (0.47) | NPY5RSMN1; SMN2KDM4EMAPTNPC1 | |
| Hydrochloric Acid SCHEMBL5774152 | 0.74 | NPY5R (0.46) | NPY5RSMN1; SMN2KDM4EMAPTNPC1 | |
| SCHEMBL5772009 | 0.74 | MEN1 (0.67) | MEN1KMT2ANPY5RSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5773195 | 0.73 | MEN1 (0.65) | MEN1KMT2ANPY5RSMN1; SMN2 | |
| SCHEMBL4652317 | 0.64 | CTSK (0.39) | SMN1; SMN2MAPTLMNA | |
| SCHEMBL5778378 | 0.63 | NPY5R (0.62) | NPY5R | |
| SCHEMBL4803387 | 0.62 | CYP1A2 (0.38) | MEN1KMT2ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL6396959 | 0.62 | CRHBP (0.47) | KMT2ASMN1; SMN2KDM4ELMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |