Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 8/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30361835 | 0.80 | GRM4 (0.47) | ADKGRM5CYP1A2 | |
| SCHEMBL5777807 | 0.80 | GRM4 (0.47) | ADKGRM5CYP1A2 | |
| SCHEMBL352291 | 0.74 | GRM5 (0.65) | GRM5KCNH2CYP1A2TDP1 | |
| SCHEMBL18343633 | 0.73 | PTGDR2 (0.43) | ADKGRM5KCNH2CYP1A2 | |
| SCHEMBL5777500 | 0.71 | RET (0.39) | ADKGRM5KCNH2 | |
| SCHEMBL1921319 | 0.70 | GRM5 (0.57) | ADKGRM5KCNH2CYP1A2TDP1 | |
| Methyl Alcohol SCHEMBL28902013 | 0.70 | GRM5 (0.67) | GRM5KCNH2CYP1A2 | |
| SCHEMBL3790627 | 0.70 | GRM5 (0.51) | ADKGRM5KCNH2CYP1A2 | |
| SCHEMBL5775196 | 0.70 | PGK1 (0.43) | GRM5TDP1 | |
| SCHEMBL31727717 | 0.70 | KDM4E (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | disclosed |