Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 7/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7184085 | 0.98 | NPY5R (0.58) | NPY5RHPGDMAPTHIF1AALDH1A1 | |
| SCHEMBL5773654 | 0.91 | NPY5R (0.52) | NPY5RHPGDMAPTHIF1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL5776456 | 0.90 | NPY5R (0.51) | NPY5RHPGDMAPTHIF1AALDH1A1 | |
| SCHEMBL5775790 | 0.90 | NPY5R (0.61) | NPY5RHPGDMAPTHIF1AALDH1A1 | |
| SCHEMBL5772713 | 0.88 | NPY5R (0.48) | NPY5RSYKPDK2PDK4 | |
| SCHEMBL5773813 | 0.86 | NPY5R (0.58) | NPY5RHPGDMAPTALDH1A1KDM4E | |
| SCHEMBL5776510 | 0.85 | NPY5R (0.44) | NPY5RHPGDALDH1A1KDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL5775998 | 0.84 | NPY5R (0.56) | NPY5RHPGDMAPTALDH1A1KDM4E | |
| SCHEMBL5769714 | 0.83 | NPY5R (0.53) | NPY5RHPGDMAPTALDH1A1KDM4E | |
| SCHEMBL5771896 | 0.80 | NPY5R (0.52) | NPY5RKDM4EL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | claimed |