Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 9/20 | 0.58 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LATS1 | O95835 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5775998 | 0.98 | NPY5R (0.56) | NPY5RBCHEACHEALDH1A1MAPK1 | |
| SCHEMBL5769714 | 0.97 | NPY5R (0.53) | NPY5RBCHEACHEALDH1A1MAPK1 | |
| SCHEMBL5773588 | 0.89 | NPY5R (0.46) | NPY5RBCHEACHEALDH1A1MAPK1 | |
| SCHEMBL5776510 | 0.88 | NPY5R (0.44) | NPY5RALDH1A1KDM4EHPGDKMT2A | |
| Hydrochloric Acid SCHEMBL5776758 | 0.87 | NPY5R (0.45) | NPY5RBCHEACHEALDH1A1MAPK1 | |
| SCHEMBL5772751 | 0.86 | NPY5R (0.60) | NPY5RALDH1A1LMNAMAPTTP53 | |
| SCHEMBL5773654 | 0.85 | NPY5R (0.52) | NPY5RALDH1A1MAPK1MAPTSYK | |
| SCHEMBL5773505 | 0.85 | NPY5R (0.56) | NPY5RALDH1A1MAPK1MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5776456 | 0.84 | NPY5R (0.51) | NPY5RALDH1A1MAPK1MAPTSYK | |
| SCHEMBL5775790 | 0.84 | NPY5R (0.61) | NPY5RALDH1A1MAPK1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | claimed |