Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.53 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.51 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777274 | 0.91 | NAMPT (0.61) | NAMPTCYP3A4GPR119ALDH1A1KDM4E | |
| SCHEMBL8702720 | 0.85 | NAMPT (0.61) | NAMPTCYP3A4GPR119ALDH1A1KDM4E | |
| SCHEMBL7496204 | 0.84 | KEAP1 (0.58) | CYP3A4GPR119KDM4EPKMCYP2C9 | |
| SCHEMBL2280397 | 0.83 | GPR119 (0.61) | NAMPTCYP3A4GPR119MAPTKDM4E | |
| SCHEMBL4325703 | 0.82 | GPR119 (0.58) | NAMPTGPR119KDM4EPKMKEAP1 | |
| SCHEMBL13398040 | 0.82 | NAMPT (0.60) | NAMPTGPR119MAPTALDH1A1KDM4E | |
| SCHEMBL29223348 | 0.81 | KMT2A (0.62) | GPR119KDM4EPKMCYP2C19 | |
| SCHEMBL2185875 | 0.81 | GPR119 (0.56) | NAMPTCYP3A4GPR119KDM4EPKM | |
| SCHEMBL5762340 | 0.80 | GPR119 (0.58) | NAMPTGPR119ALDH1A1KDM4EPKM | |
| SCHEMBL23791367 | 0.79 | GPR119 (0.59) | NAMPTGPR119MAPTKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931078-B1 | NOVEL TRICYCLIC PIPERIDINYL COMPOUNDS USEFUL AS INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORP (US) | 2006-11-15 | — | — | EP | disclosed |
| US-5965570-A | PHARMACEUTICAL COMPOSITIONS FOR INHIBITING THE ABNORMAL GROWTH OF CELLS; ADMINISTERING TO INHIBIT TUMOR CELLS WHEREIN THE RAS PROTEIN IS ACTIVATED AS A RESULT OF ONCOGENIC MUTATION IN GENES OTHER THAN THE RAS GENE | SCHERING CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0931078-A1 | NOVEL TRICYCLIC PIPERIDINYL COMPOUNDS USEFUL AS INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1999-07-28 | — | — | EP | disclosed |
| WO-1998011098-A1 | NOVEL TRICYCLIC PIPERIDINYL COMPOUNDS USEFUL AS INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1998-03-19 | — | — | WO | disclosed |